pH Balance

Recent Scientific Research on Cancer and Alkalizing

Several scientific research studies have been done showing the benefits of an alkaline lifestyle and diet like that developed and researched by Dr. Robert O. Young and Shelley Young. Examples include in vitro, animal and human studies. The first of many studies that we want to share with you indicates that the external pH of solid tumors are acidic as a consequence of increased metabolism of glucose (a me…tabolic acid) and poor perfusion. The second study shows that acid-mediated tumor invasion is plausible through mathematical modeling.

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

Abstract:

The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivo metastases. Here, we show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. NaHCO3 therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intr avasation. In contrast, NaHCO3 therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. In tail vein injections of alternative cancer models, bicarbonate had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma. Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease. [Cancer Res 2009;69(6):2260–8]

To read this entire article follow this link: The Cancer Research Journal 1

Acid-Mediated Tumor Invasion: a Multidisciplinary Study

Abstract:

The acid-mediated tumor invasion hypothesis proposes altered glucose metabolism and increased glucose uptake, observed in the vast majority of clinical cancers by fluorodeoxyglucose-positron emission tomography, are critical for development of the invasive phenotype. In this model, increased acid production due to altered glucose metabolism serves as a key intermediate by producing H+ flow along concentration gradients into adjacent normal tissue. This chronic exposure of peritumoral normal tissue to an acidic microenvironment produces toxicity by: (a) normal cell death caused by the collapse of the transmembrane H+ gradient inducing necrosis or apoptosis and (b) extracellular matrix degradation through the release of cathepsin B and other proteolytic enzymes. Tumor cells evolve resistance to acid-induced toxicity during carcinogenesis, allowing them to survive and proliferate in low pH microenvironments. This permits them to invade the damaged adjacent normal tissue despite the acid gradients. Here, we describe theoretical and empirical evidence for acid-mediated invasion. In silico simulations using mathematical models provide testable predictions concerning the morphology and cellular and extracellular dynamics at the tumor-host interface. In vivo experiments confirm the presence of peritumoral acid gradients as well as cellular toxicity and extracellular matrix degradation in the normal tissue exposed to the acidic microenvironment. The acid-mediated tumor invasion model provides a simple mechanism linking altered glucose metabolism with the ability of tumor cells to form invasive cancers. (Cancer Res 2006; 66(10): 5216-23)

To read this entire article follow this link: The Cancer Research Journal 2

References:

(1) Ian F. Robey, Brenda K. Baggett, Nathaniel D. Kirkpatrick, Denise J. Roe, Julie Dosescu, Bonnie F. Sloane, Arig Ibrahim Hashim, David L. Morse, Natarajan Raghunand, Robert A. Gatenby and Robert J. Gillies (2009). “Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases”. American Association for Cancer Research 69: 2260.

http://cancerres.aacrjournals.org/cgi/content/full/69/6/2260.

(2) Robert A. Gatenby, Edward T. Gawlinski, Arthur F. Gmitro1, Brant Kaylor, and Robert J. Gillies (2006). “Acid-Mediated Tumor Invasion: a Multidisciplinary Study “. American Association for Cancer Research 66: 5216-5223.

http://cancerres.aacrjournals.org/cgi/content/full/66/10/5216.

A pH Testimony

I just wanted to let you know I started the PH Miracle way of life 3 weeks ago and feel better than I have in years!

I am 66 years old, soon to be 67, diagnosed with fibromyalgia many years ago and lived on acetaminophen with codeine #3 and #4 taking 8-9 tablets a day. I could not walk through the grocery store, hanging onto a cart, and not feel like I was going to pass out from the pain by the time I left. Now I don’t.

Life long extensive digestive and bowel problems, I took prescription drugs for these problems for most of my life. Now I don’t. I also had a major perspiration problem. Just getting ready for work in the mornings, standing in front of the mirror in the bathroom, sweat would pour off of me like a waterfall. I quit wearing make-up because of it. Now I don’t.

Just 2-3 days after starting the PH Miracle way of eating, I no longer take pain pills, I’m not sweating!!! and I have started walking a mile in 15-20 minutes on my lunch hour and I cannot believe the lack of pain, exhaustion and sweat when I return!

My daughter Shari had 6 craniotomies between April and September of 2004 due to a head injury. She researches healthy living constantly. She found your book and we went to a seminar at Green Acres in Wichita KS and it has changed both our lives. We want to thank you and thank God for you. Blessing to you and your wife.

From Dr Robert O Young

articlesofhealth.blogspot.com